The Sysmex CA-6000 automated coagulation analyzer (Dade International) is a new random access instrument that is capable of performing 20 clot-based and chromogenic assays.
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Sysmex CA 6000
The purpose of this study is to determine whether the CA-6000 demonstrates performance characteristics for prothrombin time (PT), derived fibrinogen (DF), activated partial thromboplastin times (aPTT), fibrinogen (FBG), thrombin time (TT), factors VII (FVII) and VIII (FVIII) activity, antithrombin (AT), and plasminogen (PLG) similar to an established coagulation analyzer, the MLA 1000C (Medical Laboratory Automation).
Samples were drawn into 32 g/L sodium citrate tubes (Becton Dickinson) and centrifuged at 1300g for 10 min before analysis or freezing. Fresh and frozen (at −70 °C, then quick-thawed with a 37 °C waterbath before analysis) plasma samples were compared contemporaneously on the CA-6000 and MLA 1000C with the same reagents (Dade, except for TT noted below). Specimens tested within normal limits by the clinical laboratory served as normal samples but were not used to determine reference intervals. Abnormal samples were identified by documented evidence of oral anticoagulant, heparin, or fibrinolytic therapy, and (or) history of liver disease, hemophilia A, or other acquired coagulopathies to include trauma and disseminated intravascular coagulation.
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